Comparative study of efficacy of different Taila snehas in snehpak kalpana with special reference to Haridradi Taila ( Medicated oil with Turmeric)

 Title:- Comparative study of efficacy of different Taila snehas in snehpak kalpana with special reference to Haridradi Taila ( Medicated oil with Turmeric)

Dr. D. R. Patil had submitted his dissertation in 1998 Year, for the P.G. degree M.D. Bhaishajyakalpana (Ayurvedic Pharmaceutics). His guide was Dr. Mrs.  Sampada Sangamnerkar & research center was Ashtang Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to University of Pune.

Dr. Patil had done a clinical study of coconut oil based Haridradi Taila in three different oil basis such as Til Taila ( Sesamum Oil) , Ground nut oil ( Bhumichanaka Taila) & coconut oil ( Narikela Taila)

Total 60 Patients of clean & fresh wound were selected (Sadyo shuddha vrana ) 20 patients were treated with Haridradi taila in coconut oil, 20 patients were treated with sesamum oil based Haridradi Taila & 20 cases were treated with ground nut oil based Haridradi Taila, in form of external application ( wound dressing) every alternate day for 10 days. The criteria of assessment were on the basis of wound length, breadth, depth, pain & discharge.

The research work was concluded as follows-

1)                          When used for wound dressing ,for 20 days ,Sesamum oil based Haridradi taila  was proved most efficient in wound healing, followed by ground nut oil based Haridradi Taila.

2)                          Coconut oil based Haridradi Taila did not shoed the quick & clean wound healing properties within 10 days.

In short Haridradi Taila based on Sesamum oil was safe & can be  recommended in the wounds of minor & medium nature for dressing.

         

The study of Shalmali (Bombax malabarica Dc) with special reference to its efficacy on mukhadushika ( Acne Vulgaris)

          Title:-The study of Shalmali (Bombax malabarica Dc) with special reference to its efficacy on mukhadushika ( Acne Vulgaris)

Dr. S. N. Rathod had submitted his dissertation in 2001 Year, for the P.G. degree M.D. Dravyaguna (Ayurvedic Pharmacology). His guide was Dr. T.  M. Nesari & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to University of MUHS.

            Dr. Rathod had done a toxicological & clinical study of Shalmali thorn on 90 patients aged between 15-30 yrs having achne (Mukhadushika) on face.

          Total 90 patients were divided into 3 groups as follows-

1)    Group A having 30 patients received local application of paste of shalmali thorns (Shalmali Kantak).

2)    Group B having 30 patients received local application of paste above said drug with internal case of known controlled drug i.e. mahatiktaka Ghruta.

3)    Group C having patients received only internally used controlled drug i.e. mahatiktaka Ghruta.

For assessment of results 3 point scale such as lesion count over face with gradation of symptoms of itching, pain, discoloration of skin & swelling & photographs were used.

          Results of clinical study indicated that Shalmali thorn lepa (ext. application) relieved in 4 symptoms of acne which was highly significant.

          The research work was concluded as follows-

Shalmali thorn powder was very effective externally as a paste  in Acne vulgaris  (Mukhadushika)

          

Study of keshya effect of Gambhari Phala (Fruit of Gmelina arborea Roxb) in Palitya (premature graying of hair)

             Title:- Study of keshya effect of Gambhari Phala (Fruit of Gmelina arborea Roxb) in Palitya (premature graying of hair)

This dissertation is submitted in 2008 Year, for the P.G. degree M.D. Dravyaguna

(Ayurvedic Pharmacology). & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to MUHS.

            Randomized single blind controlled clinical trial on 60 patients of 10-35 yrs age group had done.  Premature graying of hair (Palitya) to assess

 (Kesharanjan effect of Gambhari fruit (Gmelina arborea Roxb).

          Total 60 patients were divided into 3 groups. In Group A 30 patient received Gambhari oil for local & nasal administration. In Group B 30 patients received sesamum (Til) oil for local & nasal administration for 3 months.

          Criteria for assessment was improvement in the signs & symptoms of hair disorder as per gradation, improvement in the quality of hair disorder & hair count test ( Total no. of black & gray hair above rt & lf ear in 1 sq.cm. area counting Before treatment & after treatment.

          The research work was concluded as follows-

1)    Gambhari fruit processed oil had significant effect in controlling the premature graying of hair & improving quality of hair by local & nasal administration for 3 months.

2)    Gambhari oil application was safer & more significant than sesamum oil.  

A study of standardization of Ashuddha( Impure) & Shuddha ( Pure) Dhattura seeds

  

Title:- A study of standardization of Ashuddha( Impure) & Shuddha ( Pure)  Dhattura seeds.

Dr. M. V. Agate had submitted his dissertation in 1999 Year, for the P.G. degree M.D. Dravyaguna (Ayurvedic Pharmacology). His guide was Dr. T.  M. Nesari & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to University of Pune.

            Dr. Agate had done standardization of purified & non purified Dhattura (Dhattura Metal) seeds.

          Dhattura is a poisonous drug hence its purification is necessary to reduce its toxic & adverse effects.

          Dr. Agate had collected samples of Dhattura seeds from local market, authenticated them & purified it by boiling the seeds in cow’s milk for 3 hours in Dolayantra. Then washed with hot water & dried.

          To evaluate purified (Shuddha) & non purified (Ashuddha) seeds, Botanical, physical chemical & standardization & toxicological study was done of both purified & non purified seeds.

          The research work was concluded as follows-

          Dhattura seeds purified with cow’s milk showed less toxicity in comparison with non purified seeds.

          Hence textual processing of purification of toxic drugs is necessary in standardization & clinical use of drug. 

Experimental measurements of madhura & Amla Rasa.

           Title: -Experimental measurements of madhura & Amla Rasa.

          Dr. V. A. Gholap had submitted her dissertation in 1999 Year, for the P.G. degree M.D. Dravyaguna (Ayurvedic Pharmacology). Her guide was Dr. A. P. Deshpande & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to University of Pune.

            Dr. Gholap had done an experimental study 10 sweet & sour (madhura – amla rasatmak) drugs to prepare a unit for the quantitative measurement of madhura amla rasa. In maximum drugs the sweet taste was the main & sour was allied.

          For this experiment, decoctions of each drugs prepared & diluted & tasted, starting form a maximum possible dilute solution where taste is not perceived. This point was considered as a starting point from that point gradually concentrated solutions of the decoctions were prepared & tasted.

          The point at which rasa was detected for first time was rasa. After that gradually concentrated solutions were prepared and tasted. The point of dilution at which the madhura –amla rasa was detected for the first time in each decoction was noted & observations were recorded.

          The research work was concluded as follows-

1:30 dilution forms a unit of madhura-Amla rasa, The Anannas was 20 units madhura amla.

1)    Madhura-amla rasa of Dadima (Punica granatum) was detected for the first time in 1:30 dilution hence recorded as weakest unit of madhura-amla rasa.

2)    Madhura-amla rasa of Anannas was detected for time in 1:650 dilutions, hence recorded as highest unit of madhura amla rasa.

3)    All the other Drugs lied in between these two extremes. Thus 1:30 dilution forms a unit of madhura-Amla rasa, The Anannas was 20 units madhura amla.

Similarly an attempt was made to establish a relationship between PH, sugar percentage and madhura amlatva of drugs. From the data collected one can say that the general consideration that the madhura rasa of particular drug is due to sugar content in it, which was not exclusively true as observed in this research work.

          But it was concluded that the drug have been high PH is of high unit.

          In this study no relation could be determined between acid percentage & its unit.

Palashbeeja choornache( Powder) Aushadhi gundharma anityacha gandupada kruminvar (common round warms) honara parinama.

  

          Title:- Palashbeeja choornache( Powder)  Aushadhi gundharma anityacha gandupada kruminvar (common round warms) honara parinama.

          Dr. V. M. Gokhale had submitted his dissertation for the P.G. degree M.D. Dravyaguna (Ayurvedic Pharmacology). His guide was Dr. A. R. Gogate & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India. This thesis is written in Marathi language & submitted to University of Pune.

            Dr. Gokhale had done Clinical study of palash seed powder (Butea monosperma) on 50 patients having round worms.

          First 25 patients received 1 gm palash seed powder 3 times a day with hot water for 15 days. The another 25 patients received 1 gm of same drug with jaggery for same period & time. The patients aging from 3 years to 10 years received 500 mg seed powder instead of 1 gm.

          The research work was concluded as follows –

When 1 gm Palash seed powder TDS with hot water for 15 days, it showed relief in the symptoms due to worms

1)    Palash seed powder was very effective to relieve the specific & general symptoms of round worm infestation as well as the symptoms of purishaja & Kaphaja type.

2)    The drug was found most effective to relieve symptoms related to digestive (Annavaha) Excretory (Purishajaha), Rasavaha & respiratory (Pranvaha) Channels.

3)    Palash seed powder did not excrete the round worms.

4)    Microscopic examination of stool showed that round worm ova were affected moderatory.

5)    Single drug palash seed powder showed adverse effects like nausea (hrullasa) & diarrhea (Dravamal pravrutti). These effects were less in jaggery vehicle group as compared to hot water vehicle group.

 

Study of Musta (Cyperas rotundus) & its clinical assessment in relation to Amapachan particularly in diseases like nawa Jwar & atisar

         Title:-“Study of Musta (Cyperas rotundus) & its clinical assessment in relation to Amapachan particularly in diseases like nawa Jwar & atisar”.  

       

          Dr. A. A. Kognole had submitted his dissertation in 1997 Year, for the P.G. degree M.D. Dravyaguna (Ayurvedic Pharmacology). His guide was Dr. S. G. Huparikar & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India & submitted to University of Pune.

            Dr. Kognole had done clinical study of musta infusion (phanta) of fever

(Ekadoshaja jwara) & Atisar to assess the digestive (amapachak) action in the dose of 40-80 ml twice / thrice/ four times in a day for the period 2 to 3 days.

          The drug was given according to group A- 6 patients (Vataja type of jwara & atisar), Group B- 12 Patients (pittaja type) & Group C- 13 patients of (kaphaja type)

          The research work was concluded as follows-

When Musta hot infusion ( Phanta) was given in a dose of 50 ml TDS for 3 days  showed good results in Pitta Kapha Fever

1)    Musta was the best digestive (Amapachak) drug.

2)    It was more effective in pittaja & kaphaja (fever) nava jwara than vataja jwara for its curative & digestive purpose.

3)    It was equally useful in vataja, Kaphaja & pittaja diarrhea (Samatisar) for its digestive & constipative action.