Experimental measurement of Tikta Rasa(Bitter Taste)

 

 

 Title:- Experimental measurement of Tikta Rasa(Bitter Taste) 

Dr. B. K. Agashe had submitted his dissertation for the P.G. degree M.D. Dravyaguna (Ayurvedic Pharmacology). His guide was Dr. A.  P. Deshpande & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to University of Pune. 

Dr. Agashe had done an experimental study on bitter taste (Tikta rasa) to prepare the unit & scale for quantitative measurement of tikta rasa.

          10 volunteers were selected for testing the taste of decoction & different dilutions of 14 bitter taste drugs. The criteria for assessment of Tikta rasa was organo leptic examination through tongue. The observations have been recorded in the tabular form.

          The research work was concluded as follows- 

          It had been proved that amongst 14 bitter taste drugs, chandan was the weakest of bitter taste series & kiratatikta was the strongest of bitter taste series.

Study of Keshya Karma( Hair Tonic) of Nirgundi.

 Title:- Study of Keshya Karma( Hair Tonic) of Nirgundi.

Dr. M. A. Bhide had submitted her dissertation in 2001 Year, for the P.G. degree M.D. Dravyaguna (Ayurvedic Pharmacology). Her guide was Dr. T.  M. Nesari & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to University of Pune.

Dr. Bhide had done clinical study on 60 patients of having hair loss (Full) complaint, to assess the hair promoting (Keshya) effect of the drug Nirgundi (Vitax nigundo).

In total 60 patients

15 patients of group A received Nirgundi Churna internally in a dose of 500 mg twice day.

15 patients of Group B received Nirgundi oil for external application.

15 Patients of Group C received Sesamum oil for external application.

15 Patients of Group D received Nirgundi oil for external application & Nirgundi churna internally.

Criteria of assessment was –

1)    Hair pull test BT & AT

2)    Hair count in 1 sq. inch area above right ear BT & AT

The research work was concluded as follows-

It was found that external application of Nirgundi oil (Group B) was significant in stopping hair loss complaint

          In short local action of Nirgundi found to be more potent may be due to removing obstruction at the hair root level by its properties such as hot potency ( Ushna virya) Pungent, Bitter taste ( Katu tikta Rasa).

Experimental measurement ( Organoleptic) of madhura rasa ( Sweet Taste)

             Title: - Experimental measurement ( Organoleptic) of madhura rasa ( Sweet Taste)

Dr. J. V. Changade had submitted her dissertation for the P.G. degree M.D. Dravyaguna (Ayurvedic Pharmacology). Her guide was Dr. S.  G. Huparikar & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to University of Pune.

            Dr. Changade had done an experimental study to develop a scale or unit for evaluation of measurement of sweet taste (Madhura rasa) drugs.

          For the study 15 drugs of sweet taste were taken in different dilutions & 10 volunteers were chooses for testing these drugs.

          The observations recorded by 2 ways-

i)                   Madhuratwa (Unit) of each drug i.e. organo leptic tongue examination (Rasana Pratyaksha) & observation were recorded in the tabular form.

ii)                The Symptoms felt by volunteers were also recorded as sweetness of mouth, freshness of mind etc.

The Research work was concluded as follows-

i)                   Between all sweet drugs sugar had shown the highest units (25Units).

ii)                Vatama was the weakest sweet drug which forms the unit of sweet taste.

iii)              Though ‘Atibala’ was mentioned in sweet drug list by various texts, organo leptically the root sample was found to be bitter astringent.

iv)              Fully ripened ‘Kadali” was found sweet.

v)                The sugar percentage of drug was directly proportional to its unit (Higher sugar content).

vi)              In this study, no relation could be determined between carbohydrate percentage & its unit.

Comparative study of efficacy of different Taila snehas in snehpak kalpana with special reference to Haridradi Taila ( Medicated oil with Turmeric)

 Title:- Comparative study of efficacy of different Taila snehas in snehpak kalpana with special reference to Haridradi Taila ( Medicated oil with Turmeric)

Dr. D. R. Patil had submitted his dissertation in 1998 Year, for the P.G. degree M.D. Bhaishajyakalpana (Ayurvedic Pharmaceutics). His guide was Dr. Mrs.  Sampada Sangamnerkar & research center was Ashtang Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to University of Pune.

Dr. Patil had done a clinical study of coconut oil based Haridradi Taila in three different oil basis such as Til Taila ( Sesamum Oil) , Ground nut oil ( Bhumichanaka Taila) & coconut oil ( Narikela Taila)

Total 60 Patients of clean & fresh wound were selected (Sadyo shuddha vrana ) 20 patients were treated with Haridradi taila in coconut oil, 20 patients were treated with sesamum oil based Haridradi Taila & 20 cases were treated with ground nut oil based Haridradi Taila, in form of external application ( wound dressing) every alternate day for 10 days. The criteria of assessment were on the basis of wound length, breadth, depth, pain & discharge.

The research work was concluded as follows-

1)                          When used for wound dressing ,for 20 days ,Sesamum oil based Haridradi taila  was proved most efficient in wound healing, followed by ground nut oil based Haridradi Taila.

2)                          Coconut oil based Haridradi Taila did not shoed the quick & clean wound healing properties within 10 days.

In short Haridradi Taila based on Sesamum oil was safe & can be  recommended in the wounds of minor & medium nature for dressing.

         

The study of Shalmali (Bombax malabarica Dc) with special reference to its efficacy on mukhadushika ( Acne Vulgaris)

          Title:-The study of Shalmali (Bombax malabarica Dc) with special reference to its efficacy on mukhadushika ( Acne Vulgaris)

Dr. S. N. Rathod had submitted his dissertation in 2001 Year, for the P.G. degree M.D. Dravyaguna (Ayurvedic Pharmacology). His guide was Dr. T.  M. Nesari & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to University of MUHS.

            Dr. Rathod had done a toxicological & clinical study of Shalmali thorn on 90 patients aged between 15-30 yrs having achne (Mukhadushika) on face.

          Total 90 patients were divided into 3 groups as follows-

1)    Group A having 30 patients received local application of paste of shalmali thorns (Shalmali Kantak).

2)    Group B having 30 patients received local application of paste above said drug with internal case of known controlled drug i.e. mahatiktaka Ghruta.

3)    Group C having patients received only internally used controlled drug i.e. mahatiktaka Ghruta.

For assessment of results 3 point scale such as lesion count over face with gradation of symptoms of itching, pain, discoloration of skin & swelling & photographs were used.

          Results of clinical study indicated that Shalmali thorn lepa (ext. application) relieved in 4 symptoms of acne which was highly significant.

          The research work was concluded as follows-

Shalmali thorn powder was very effective externally as a paste  in Acne vulgaris  (Mukhadushika)

          

Study of keshya effect of Gambhari Phala (Fruit of Gmelina arborea Roxb) in Palitya (premature graying of hair)

             Title:- Study of keshya effect of Gambhari Phala (Fruit of Gmelina arborea Roxb) in Palitya (premature graying of hair)

This dissertation is submitted in 2008 Year, for the P.G. degree M.D. Dravyaguna

(Ayurvedic Pharmacology). & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to MUHS.

            Randomized single blind controlled clinical trial on 60 patients of 10-35 yrs age group had done.  Premature graying of hair (Palitya) to assess

 (Kesharanjan effect of Gambhari fruit (Gmelina arborea Roxb).

          Total 60 patients were divided into 3 groups. In Group A 30 patient received Gambhari oil for local & nasal administration. In Group B 30 patients received sesamum (Til) oil for local & nasal administration for 3 months.

          Criteria for assessment was improvement in the signs & symptoms of hair disorder as per gradation, improvement in the quality of hair disorder & hair count test ( Total no. of black & gray hair above rt & lf ear in 1 sq.cm. area counting Before treatment & after treatment.

          The research work was concluded as follows-

1)    Gambhari fruit processed oil had significant effect in controlling the premature graying of hair & improving quality of hair by local & nasal administration for 3 months.

2)    Gambhari oil application was safer & more significant than sesamum oil.  

A study of standardization of Ashuddha( Impure) & Shuddha ( Pure) Dhattura seeds

  

Title:- A study of standardization of Ashuddha( Impure) & Shuddha ( Pure)  Dhattura seeds.

Dr. M. V. Agate had submitted his dissertation in 1999 Year, for the P.G. degree M.D. Dravyaguna (Ayurvedic Pharmacology). His guide was Dr. T.  M. Nesari & research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India, & submitted to University of Pune.

            Dr. Agate had done standardization of purified & non purified Dhattura (Dhattura Metal) seeds.

          Dhattura is a poisonous drug hence its purification is necessary to reduce its toxic & adverse effects.

          Dr. Agate had collected samples of Dhattura seeds from local market, authenticated them & purified it by boiling the seeds in cow’s milk for 3 hours in Dolayantra. Then washed with hot water & dried.

          To evaluate purified (Shuddha) & non purified (Ashuddha) seeds, Botanical, physical chemical & standardization & toxicological study was done of both purified & non purified seeds.

          The research work was concluded as follows-

          Dhattura seeds purified with cow’s milk showed less toxicity in comparison with non purified seeds.

          Hence textual processing of purification of toxic drugs is necessary in standardization & clinical use of drug.